Sleep Deprivation Increases Risk Of Clogged Leg Arteries: Study
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First, the researchers analysed the associations of sleep duration and daytime napping with the risk of PAD. In the second part, they used genetic data to perform trials to examine the cause behind these associations.
"Observational analyses are limited by reverse causality- meaning that if an association between sleep habits and PAD is found, we cannot be certain if sleep habits caused PAD or having PAD caused the sleep habits," Yuan said. Taken together, the strongest evidence was for a short sleep, where the relationship with PAD went both ways.
In an observational analysis of 53,416 adults, sleeping less than five hours a night was associated with a nearly doubled risk of PAD compared with seven to eight hours, the researchers said. This finding was supported by further analyses in 156,582 and 452,028 individuals. In the causal studies, short sleep was associated with an increased risk of PAD and, in addition, PAD was associated with an increased likelihood of short sleep.
"The results indicate that brief night-time sleep can raise the chance of developing PAD and that having PAD increases the risk of getting insufficient sleep," said Yuan. Regarding long sleep, in an observational analysis of 53,416 adults, sleeping eight hours or more per night was linked with a 24 percent higher risk of PAD compared with seven to eight hours.
This finding was supported by analyses in two larger populations of 156,582 and 452,028 individuals. However, no causal relationships were found between long sleep and PAD, the researchers said.
"More studies are needed on the relationships between lengthy night-time sleep, daytime napping, and PAD," Yuan added.
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