Overweight In Youth Increases Risk Factor For Blood Clot In Adult Life: Study
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Distinctly Elevated Thrombus Risk
It emerges from the results, now published in the Journal of Internal Medicine, that BMI at both ages 8 and 20, independently of each other, can be linked to venous blood clots. These may occur in, for example, the leg (deep vein thrombosis, DVT) or the lung (pulmonary embolism).In adulthood, two groups were found to be at a significantly increased risk of venous thrombi. The first was individuals who had been overweight both as children and as young adults, while the second was composed of those whose weight in childhood was normal and who became overweight only in early adulthood.
Moreover, being overweight in both childhood and young adulthood was found to raise the risk of arterial thrombi -- that is, clots resulting from constricted blood vessels with fatty deposits and inflammation. Since there were few cases of arterial blood clots in the study, however, further studies are needed to confirm these findings. All comparisons in the study were made with the control group, whose weight was normal at both 8 and 20 years of age.
Overweight In Puberty An Important Factor
The first and corresponding author of the study is Lina Lilja, a doctoral student at Sahlgrenska Academy, University of Gothenburg, and pediatrician. At the time of the study, she worked at the Kungshojd pediatric clinic in Gothenburg. Today, she is a senior physician in child health care in Region Vastra Gotaland. "Our study shows that both being overweight in childhood and overweight in young adulthood increase the risk of venous blood clots later in life. The latter, overweight when the men were young adults, proved to be a more influential factor than overweight when they were children," Lilja notes.
Professor and senior physician Claes Ohlsson and associate professor and senior physician Jenny Kindblom, both of Sahlgrenska Academy at the University of Gothenburg and Sahlgrenska University Hospital, were senior authors of the study.
"Obesity and overweight during puberty seem to have a marked impact on a person's future risks of venous thrombi," Kindblom concludes. The study includes data from the BMI Epidemiology Study (BEST) in Gothenburg, a population study, and from Swedish national registers.
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Thursday, March 16, 2023 at 8:52 am