Metformin may prevent severe morning sickness

Published: Wednesday, July 9, 2025 at 4:40 pm

Metformin Shows Promise in Preventing Severe Morning Sickness

A recent survey-based study suggests that the common diabetes drug metformin may significantly reduce the risk of hyperemesis gravidarum (HG), a severe form of morning sickness. The study, published in the *American Journal of Obstetrics and Gynecology*, indicates that taking metformin before pregnancy could lower the risk of HG by over 70%.

HG, characterized by extreme nausea and vomiting, can lead to serious complications during pregnancy, including weight loss, dehydration, and electrolyte imbalances. It can also have long-term health implications for both the mother and the baby. The study involved over 5,400 participants who completed an online questionnaire about their medication use and pregnancy experiences.

Researchers found that metformin, which is known to increase levels of a hormone called GDF15, was associated with a substantial decrease in HG risk. GDF15 is believed to play a role in morning sickness, with lower pre-pregnancy levels potentially increasing sensitivity to the hormone's rise during pregnancy.

While the findings are encouraging, experts emphasize that the study is based on self-reported data and a clinical trial is needed to confirm the results. Further research will also be necessary to determine the optimal dosage and timing of metformin administration.

BNN's Perspective: This research offers a glimmer of hope for those who suffer from severe morning sickness. While it's crucial to await the results of clinical trials, the potential for metformin to prevent HG could significantly improve the quality of life for many pregnant individuals and potentially influence family planning decisions.

Keywords: metformin, morning sickness, hyperemesis gravidarum, HG, pregnancy, GDF15, diabetes, nausea, vomiting, clinical trial

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