Dieting: Brain Function Changes During A Diet, Claims Study
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Researchers from the Max Planck Institute for Metabolism Research and Harvard Medical School have now shown in mice that communication in the brain changes during a diet: The nerve cells that mediate the feeling of hunger receive stronger signals, so that the mice eat significantly more after the diet and gain weight more quickly. In the long term, these findings could help develop drugs to prevent this amplification and help to maintain reduced body weight after dieting.
"People have looked mainly at the short-term effects of dieting. We wanted to see what changes in the brain in the long term," explains Henning Fenselau, a researcher at the Max Planck Institute for Metabolism Research, who led the study. To this end, the researchers put mice on a diet and assessed which circuits in the brain changed. In particular, they examined a group of neurons in the hypothalamus, the AgRP neurons, which are known to control the feeling of hunger.
They were able to show that the neuronal pathways that stimulate AgRP neurons sent increased signals when the mice were on a diet. This profound change in the brain could be detected for a long time after the diet.
Monday, April 3, 2023 at 7:30 am