Alzheimers Fully Reversed in Mice, Scientists Say

Published: Monday, December 29, 2025 at 12:00 pm

Scientists Report Alzheimer's Reversal in Mice Using Novel Compound

A team of American scientists has announced a breakthrough in Alzheimer's research, claiming to have reversed the disease in lab mice. The study, published in the journal *Cell Reports Medicine*, involved researchers from Case Western Reserve University, University Hospitals, and the Louis Stokes Cleveland VA Medical Center. The researchers utilized the compound P7C3-A20 to achieve these results.

The study's principal investigator, Andrew A. Pieper, emphasized the hopeful implications of the findings, suggesting that the damage caused by Alzheimer's may not be irreversible. The research is part of a growing body of promising lab studies exploring potential treatments for Alzheimer's and other neurological conditions.

The scientists focused on the role of NAD+, a crucial molecule for cellular metabolism that declines with age and is depleted in Alzheimer's patients. The study involved two groups of mice genetically predisposed to Alzheimer's, one with amyloid protein mutations and the other with tau protein mutations. The compound P7C3-A20 was administered to both groups. In one group, the treatment prevented the disease from developing. In another group, the compound was administered to mice already suffering from advanced Alzheimer's, resulting in a complete recovery of cognitive function and restored NAD+ levels.

The researchers highlight that P7C3-A20 offers an alternative to over-the-counter NAD+ precursors, which can potentially lead to toxic levels and increase cancer risk. The team is planning to move to human clinical trials.

BNN's Perspective:

This research offers a significant glimmer of hope in the fight against Alzheimer's. While the findings are promising, it is crucial to approach them with cautious optimism. The transition from animal studies to human trials is a complex process, and the results may not be directly transferable. However, the potential for a treatment that could reverse the effects of Alzheimer's is a significant development that warrants further investigation and support.

Keywords: Alzheimer's, mice, P7C3-A20, NAD+, cognitive function, treatment, research, amyloid, tau, neurological, disease, cure, recovery, cellular metabolism, clinical trials

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